Chapter 60: Research on Coenzymes

The reason why Yang Rui's real yàn room is affiliated with and procures equipment through the Xibao Meat Factory is because there is a biochemical pharmaceutical team under the Xibao Meat Factory.

Some people may find it strange how there can be a pharmaceutical workshop in the meat factory, but in fact, until the 90s, most of the biochemical pharmaceutical factories in China were located in the meat factory.

This is determined by the nature of the biochemical pharmaceutical factory, the primary biochemical pharmaceutical is produced with animal organs, you want fresh animal offal, and there is no good means of preservation and transportation, do not set up the factory in the meat factory, where can it be located?

At this time, the biochemical pharmaceutical factory is not called a biochemical pharmaceutical factory, it is generally called an organ biochemical factory, or a visceral biochemical workshop, the scale is not large, and the Xibao meat factory has only a team of more than ten people.

Journals and books related to biopharmaceuticals are either called "Organ Biochemical Pharmaceuticals" or "Animal Biochemical Pharmaceuticals" at this time. The microbial fermentation method and plant cell culture method commonly used in later generations are still being studied, not to mention the chemical synthesis method, which is always the most difficult and the last method to be popularized.

There are many organs that can be used in medicine, such as insulin and pancreatic enzymes from the pancreas, coenzymes from the heart, and cholesterol from the brain...... In '82, all biological products were expensive and marketable.

However, the biochemical and pharmaceutical team of Xibao Meat Factory is not taken seriously, and their most profitable project is the export of white strip meat to Europe, which earns millions of dollars in foreign exchange every year, and is also the proud capital of the factory leaders.

In contrast, although the products of organ pharmaceuticals are valuable, the cost is also very amazing, with the method of the 80s, one kilogram of organs may only be able to extract dozens of milligrams of products, and other solvents and materials will be consumed during the period, and the gains outweigh the losses. Moreover, the biochemical products that are relatively common in the 21st century, the biochemical pharmaceutical team of Xibao Meat Joint Factory can't make them, and in terms of their technology, he is not cheap what others can do, and he can't do what others can't do.

Of course, Yang Rui does not have such a problem.

After 30 years of development, he is using the practice of the real yàn room of later generations, and the output is higher than that of the biochemical team of the Xibao Meat Factory. Of course, the scale of the biochemical team of the Xibao Meat Joint Factory is actually the scale of the real yàn room, but there are a few more people.

Yang Rui is not ready to sell biochemical products directly to make money, these things are still a model of full monopoly by the state, it is more troublesome for individuals to make a lot of money, and it is also very tiring, continuous production is that long-trained workers are prone to error, not to mention him and a group of students.

It is estimated that it is feasible to win the honor, but Yang Rui cares the most.

Instead of making less money in exchange for honor, Yang Rui is more willing to lay some papers.

When he was in graduate school, he spent most of his time looking through papers for his teachers. Normally, when the tutor makes a list, he has to look up the information for a week, and it is impossible to say that the journals and books he has read are well understood, but he has to scan them anyway.

As a result, these papers are now reflected in his mind.

Yang Rui only needs to choose some simple ones to redo the real yàn, and then rewrite it.

As for how simple it is to be able to make his small real room work, Yang Rui's judgment method is the price of the real equipment.

The simpler the equipment, the better, the less the instrument, the better, the simpler the better, and the easier the raw materials to buy, the better.

After such screening, Yang Rui selected the relevant research of coenzyme Q10.

Enzymes are the catalysts for the work of organisms, and coenzymes are the so-called "second substrates" that assist enzymes in their work, and the common coenzymes are vitamin B1, vitamin B2, folic acid and so on. These cheap coenzymes were produced by chemical synthesis, and the cost of a bottle could be reduced to a few cents, but in the beginning, they were still obtained by extraction. For example, folic acid, which all pregnant women eat, was first isolated from spinach leaves, hence the name.

From this point of view, the so-called diet therapy in China is somewhat meaningful.

Coenzyme Q10 is a relatively late coenzyme that was originally extracted from animal heart tissue. It's been a long research process.

As early as 1974, Eisai Pharmaceutical Co., Ltd. in Japan sold it as a heart drug, and it attracted the attention of many biologists. As a result, in the following years, three international symposiums were held in one go, and extensive research was conducted on its biomedical and clinical applications, and China also made coenzyme Q10 in 1976.

Until the time of Yang Rui's crossing, coenzyme Q10 was still a research hotspot, biologists were still studying its biomedical and clinical applications, and pharmaceutical companies were still studying its production methods.

In 1982, CoQ10 was naturally more valuable, both as a product and in a research paper.

It is precisely because 30 years later, coenzyme Q10 is still a research hotspot, Yang Rui has been able to read many related papers, as long as the equipment is in place, he can copy a basket of articles.

In fact, experts and professors at home and abroad who have relied on the research of coenzyme Q10 for a lifetime are all over the place, and if they cut off their ears, they can almost fit a basket.

Adhering to the idea of low-key accumulation, Yang Rui first purchased beakers, flasks, triangular flasks and other instruments, ethanol, propanol, butanol and other reagents in the name of the school, and then directly ordered two batches of coenzyme Q10 refined products from Pingjiang Biochemical Pharmaceutical Factory in the name of the biochemical pharmaceutical team of Xibao Meat Factory.

He plans to write an article on how to measure coenzyme Q10 more accurately, which is not weaker than the direct production of coenzyme Q10, but it will be simpler.

While waiting for the things to arrive, Yang Rui began to tutor the members of the Rui Xue group in biology, and at the same time selected his own practical assistants.

Li Tieqiang and others will continue to come to the classroom to listen to classes, but they can no longer get test papers for free, and Yang Rui will not mark the test papers for them, let alone make targeted course tilts.

For students who have not enjoyed this kind of treatment, it may be difficult for them to understand the effect of the so-called tilt, but for Li Tieqiang and others, who have enjoyed special treatment, they immediately feel the change.

It was difficult to improve the performance highly.

They couldn't say why, but they panicked even more.

Someone took advantage of the night to find Yang Rui, hoping to rejoin the Rui group, but was blocked by Cao Baoming, who was in the same room, without hesitation.

Li Tieqiang and Wang Wanbin also tried to talk in the cafeteria, but they were still rejected without hesitation.

At the same time, the curriculum of the Ruixue group has gradually progressed from reviewing junior high school, relearning high school, to real high school review.

More difficult questions and more complex review routes have further widened the distance between the Ruixue group and other students.

At this time, Li Tieqiang and others regretted it even more, but they were also in vain.

Yang Rui had so many cards in his hand that he didn't have to say anything or do anything to completely shut them out.

And the more insipid the treatment, the more infuriating it is.

Li Tieqiang and Wang Wanbin simply pulled more than a dozen people, organized their own study group, and then studied hard, encouraged each other, and tried in vain to surpass the Ruixue group.

However, they themselves are all old students who have been trying to repeat their studies for two or three years, and if the old methods are useful, why should they repeat them year after year.

What's more, the members of the Ruixue group are studying diligently in a more scientific curriculum schedule, and the gap between the two sides will only widen, but it will not narrow.

A week later, when Yang Rui's first batch of simple instruments arrived, there were only two or three people left in the newly formed study group, and they were dead in name.

More people are looking at this real room.

In the history of Xibao Middle School, there has never been such a configuration as a real yàn room.

Even Principal Zhao couldn't help but come to this small house by the garden, observing and caressing those simple flasks, burettes, pH test strips and other things one by one, and sighed: "It would be good if you came to school two years earlier, and Lao Tan might be able to stay." ”

Lao Tan is a chemistry teacher at a university, and because of **** reasons, he ran to Xi County, and was later protected by Principal Zhao. However, in the year Yang Rui was in high school, Lao Tan returned to the city with rehabilitation.

Yang Rui disagreed with President Zhao's emotion, and said with a smile: "The current configuration of this real room is not as good as the middle school in the provincial capital, and it is not as good as a real room in Hedong University. ”

"Why is teaching a waste?" Principal Zhao knew that he was right, but he still didn't want to admit it, shook his head and said: "I think your real room is good enough, what do you want, there are more bottles and cans than in the first middle school, what real yàn can't do?"

Yang Rui said: "The real yàn room of No. 1 Middle School is for teaching, what kind of strength do I compare with them." Moreover, in terms of assets, this real yàn room is currently only worth 1,000 yuan, how can the real yàn room in the first middle school cost tens of thousands. ”

". It was in 78 that they received a batch of real instruments, otherwise, they would still be poor and white. Principal Zhao turned his face as he spoke, rubbed his hands and said, "Otherwise, let the students of our school also come to your room to do the real thing?"

Yang Rui stretched out his hands and said: "To do it is to consume materials, if you are willing to pay for reagents or something, I can substitute for free." ”

Principal Zhao was stunned for a moment and asked, "How much money do you have for materials?"

"A person is a few cents at a time, and it depends on what he does, and an average of two cents is wanted. "In the 80s, prices were cheap, but consumables weren't cheap.

Principal Zhao quickly mentally calculated, there are more than 400 people in the school, and if they do it once a month, they will get at least 100 yuan of funds, and for four months in a semester, it will be four or five hundred yuan.

Coming to this result, Principal Zhao immediately changed his words: "It's too troublesome to be real, it's just such a big room...... Let's let the students visit for free. ”

Yang Rui wanted to say, can a free visit make the room bigger?

However, looking at the curious appearance of the surrounding classmates, Yang Rui couldn't help but soften his heart and said, "Let's visit." However, if it's just a free visit, I won't deliberately arrange the actual content, and it's up to me to explain or not, and the discipline of the visit has to listen to me. ”

"No problem. ”

"Don't go by class, let interested students sign up, and I will inform them of the time, so that I can reduce the pressure of visiting. ”

"No problem. ”

"The students who came to visit wanted to help me clean the real room and help clean the real equipment. ”

"No problem. ”

"That's it, if there are really interested students, I will find an opportunity to arrange for them to do it themselves. Yang Rui didn't wait for Principal Zhao to speak, and then continued: "The number of people can't be large, the school has no funds, and I don't have either." ”

If you really want to learn something through guò, it is at least to operate once every half a month, it is 1,000 yuan in a semester, and 2000 yuan in a year, and Yang Rui can't afford it.

Principal Zhao nodded without hesitation, and then put forward his own request: "If someone comes to visit in the future, you have to say that the yàn room is from the school." ”

"Whatever, anyway, the instrument is in my name. "Yang Rui still has an invoice in his hand.

Principal Zhao ignored Yang Rui's Xiao Jiujiu, touched his beard and said: "Shengli Middle School paved a cinder road last year, and Dong Goozi invited me to visit it twice, and I have to recruit this field back." ”

"You have to give advance notice if someone is visiting, otherwise don't blame me for the closed padlock. Yang Rui made a small threat, he actually didn't care that someone came to see him, writing a paper is to be famous, and showing a real room is the same as being famous.