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June 21, 1621.

The English sailing ship "Hound Dog", which was rescued by the whaling ship Mermaid more than a month ago, has finally been repaired in dry dock. During the repair process, the Hound with more sophisticated and concise internal and external structures aroused great interest to the young shipyard director Shi Yige, who spent most of his time surveying and mapping the ship's structure for more than a month.

Today's third voyage to Europe is a spectacular flotilla. The Santa Maria, St. Nicholas, Wenwen and the renovated Hound have filled the Manhattan community with a sense of fulfillment and excitement.

Boatswain's men were promoted to acting captains of the fleet, and the average number of sailors on each ship was less than 20, and many of the crew members were new Europeans who had been in the company for less than three months, so at the insistence of Adelaide, the commander-in-chief of the fleet, and Ren Changle, the chief accountant, several additional soldiers of the land garrison were stationed on each ship to ensure the safety of the ships.

It has only been more than a month since the second voyage to Europe, and such frequent trade voyages have made it impossible for the Brooklyn Industrial Area to prepare enough goods to fill the holds, but the European Azores Armagnosís-Fort Heroísmo is squeezing a large number of living, industrial and agricultural raw materials waiting to be transported back to North America, and the cargo carried by the guide this time is only enough to fill two and a half ships.

The 2,000 Type 21B flintlock rifles were one of the main items of the shipment, followed by 300 boxes of soap or soap produced from blubber, 100 sets of fine glass wine sets that had been flowing from Europe, thousands of mirrors made from the mercury that had been shipped last time, less than 2,000 furs that had been reluctantly purchased after the last clearance, and finally 1 kilogram of berberine, a mass killer jointly launched by the Ministry of Chemical Industry and the Ministry of Medicine.

With hydrochloric acid, the so-called berberine can be extracted from the Ranunculaceae family Coptis chinensis as a raw material, and the whole preparation process is extremely simple.

The different alkaloid components and contents are not only limited to the treatment of gastrointestinal infections such as dysentery, but also have a wide range of powerful antibacterial and anti-inflammatory effects for internal and external use, and can even be used for wound disinfection and sterilization when dissolved in water.

Since there is no real pharmaceutical process for formal processing, it is predictable that this purified substance, which does not even have a sugar coating, is definitely the most bitter thing that Europeans have ever come to their hands on, and its value is far more than the same weight of gold.

A small sealed glass tube contains 1 gram of berberine powder, and the ** silk of the Ministry of Chemical Industry told Ren Changle that such a daily dosage of berberine is worth at least 2 pounds, and don't sell it as Chinese cabbage.

Therefore, the main role of these 1,000 berberine is to serve as a marine preparation drug, rather than a complete export, to replace the modern gastrointestinal drugs previously equipped for each ship. With a limited stock of modern medicines, the community council must be careful with its budgets.

In this way, the total value of the cargo carried by the entire fleet will exceed that of the first two European trades, amounting to a staggering 1.8 million Spanish silver dollars. Of course, it is impossible to sell all such valuable goods in Porto Heroísmo in the Azores in a short period of time.

Amid the waves and cheers on the riverbank, and the smiling farewells of several members of the community committee, the four sailboats slowly galloped away from the docks in the industrial area of Brooklyn and then turned south.

……

……

It's dusk, but it's still busy in a small two-story building in the northwest corner of Manhattan.

Several young men and women in lab coats gathered around an elderly woman in a wheelchair, looking intently at a row of glass petri dishes in the center of the room.

The room is painted pure white, which looks extremely clean, many of the table work equipment is a rare stainless steel structure, and even an air conditioner is installed that I don't know which ship to disassemble from, so that the temperature in the room is kept constant at all times. In terms of the atmosphere and facilities alone, it is the closest thing to a modern research room style in the entire Manhattan community, and from the outermost door number of the house, it also makes every community resident who passes by awe.

The medical research group is directly subordinate to the medical department of the community committee, and the leader is Huang Nian, the wife of the new judicial committee member of the community committee, a lecturer in the biology department of a university.

The comminuted fracture of the lower limb caused the catastrophic leader to almost become the first person among all the seriously injured who could not survive the crisis. Although he was finally saved by the superb medical skills of Chen Yuanyuan, the director of the community hospital, Huang Nian had to use a wheelchair to live from then on.

After carefully looking at the last petri dish, the old man Huang Nian shook his head slightly. I saw that on the surface of the agar in the petri dish, there was a faint circle of hydrolysis traces in the center of a golden colony.

"Mr. Huang, among the 20 samples in this batch, this effect is the best." A young man with glasses carefully lowered his head and pointed to the petri dish that was placed in front of the old man Huang Nian, "Now the agar extraction is more troublesome, and the next batch of real yàn will not start in at least a week." ”

"No. 17 seems to be the most effective, but it's still far from the actual penicillium strains available. Huang Nian covered the petri dish, and under the impetus of the students, he came to the wall of the room again, took out a wooden pole, and pointed to a large white paper on the wall.

"Penicillin extraction is not really an advanced technology, the real difficulty is to find the right strain. Historically, although the discovery of penicillin by Americans was more like a coincidence, it took nearly 20 years for the industrial mass production of penicillin to find the most suitable parent of penicillium strains in the continuous practice. ”

Huang Nian smiled and pointed to a row of petri dishes on the test bench in the distance, and then looked at a few young people who were assigned to this real department, and sighed secretly in his heart.

"But Mr. Huang, we have been taking samples from various moldy plants for culture, and there are samples with good results, but why do you always say that it is not suitable?" A girl looked at the notebook in her hand with a little trepidation.

"Actually, we did it very inhumanely...... Those penicillin samples used on Indian patients, the toxicity table is stricter than the antibacterial effect......" Huang Nian's eyes darkened a lot, and the feelings were not very good, "The antibacterial effect and toxicity of Penicillium are coexisting, and to find a strain with low toxicity and higher antibacterial effect, the only way to obtain the effective number can only be obtained through continuous clinical trials." Maybe our sample range is still too small. ”

"I found everything I could find, and I did more than 400 culture tests...... Isn't sulfonamide better, why do we have to die with penicillin. The bespectacled young man muttered softly, a little discouraged.

"We have accumulated more knowledge than our predecessors, and we can avoid many detours, but there is really no trick in finding high-quality penicillin strains except for time, perseverance and luck." Huang Nian looked kindly at the only young man majoring in pharmacology in a university in front of him, knowing that such a knowledgeable young man was guilty of a common problem in the scientific research industry, "You are studying pharmacology, and the effect of sulfonamides is not a one-trick one-size-fits-all, and it is easier to develop drug resistance...... Much of our work has to be forward-looking in order to ensure that we don't lose sight of what we do in the future. ”

"Teacher Huang, what can we gain by staying in the real yàn room all day long like us? They went to Europe, went to trade, and as soon as the results were produced, they were all praised, even if they were skilled workers in industrial areas, they were more beautiful than us, and they lived a comfortable and leisurely life...... Although there is a lot of material supply here, it is all for us to do something in the future, and it is also the production department and the trade department that will continue to be popular, including the berberine extraction process last time, except for a bonus to fool people, we have no benefit! What is the difference between this and before the crossing, it is still not as good as setting up a stall in scientific research! ”

The young man with glasses is not a brainless literary and artistic youth, but a little excited to shake his hand. The people around them silently bowed their heads, and seemed to agree.

Make a huge selfless contribution to the cause of human health? Or is berberine, penicillin, and those products that appear in factories just something that should be taken for granted, and simply not worth paying attention to?

The old man Huang Nian was stunned for a moment, looking around at several young men and women who had been assigned to him as students and real members, and there were bursts of irrepressible sadness in his heart.

……

……

A few time zones away, Su Zining, who had successfully completed a trip to the Netherlands, was sailing the waters of the Bay of Biscay on a purchased sail galen.

The Mayflower remains the flagship, followed by the 400-ton Shepherd, which is already a bit old, followed by the 280-ton Goblin and the 320-ton Eden, both of which are new ships less than a year old. Today, the three official Dutch sailboats are loaded with large quantities of textile fabrics and industrial raw materials, as well as more than 300 European artisans or refugees who have undergone strict quarantine.

It was already almost midnight, and the western wind blowing from the Atlantic Ocean was a little bumpy for the crosswind-driven fleet. Su Zining, dressed in a thin shirt, was still leaning on the side of the ship, quietly looking at the sea in the west with a faint windproof oil lamp on the deck.

"Su Zining, why are you still on deck so late today?"

A familiar voice came from behind her, and the female translator Yuan Xinyi walked over with a suit jacket. The female translator, who had been dressed in palace costumes during her trip to the Netherlands, finally changed into a Western-style dress that was more convenient for her to move around.

"It's still beautiful in gorgeous clothes...... Su Zining took the coat and didn't put it on, but looked at his companion a little and showed a faint smile.

"What are you covering...... You don't seem to be in a good mood? Yuan Xinyi pursed her lips, secretly happy in her heart, so she showed concern, "What are you doing in the West, do you want to go back to Manhattan?" ”

Looking at each other's eyes quietly, Su Zining shook his head slightly: "I'm thinking, what can protect us through these years." I used to think that in the 17th century, the Atlantic Ocean was the greatest safeguard, followed by the current war on the European continent, but now I find myself more and more naïve in my original thinking......"

"Isn't it? Everywhere we passed, there were refugees and beggars, and the war would last for thirty years! Yuan Xinyi looked at the other party's serious expression strangely, "Aren't these all what you have been emphasizing?" ”

"Well, but that's just where we're seeing at the moment. In the Thirty Years' War, there were also two European countries that were unaffected or had little impact, but ultimately benefited - England and France. Even the Netherlands, if there is less containment, will be free from a lot of burdens in a few years. ”

Su Zining pointed to the West and continued: "Although Britain is now experiencing a historical parliament and a king's dispute, their maritime policy has not been affected, and the colonization of Virginia in New England has not been broken; France took advantage of the Thirty Years' War, and the first semi-permanent colonial trading post of the French had been established long ago at the mouth of the St. Lawrence River in Canada, and the town forts of Quebec had been in shape many years earlier. ”

"What do you mean?" Yuan Xinyi was a little confused.

"England and France will eventually sandwich our development space from two directions, one south and one north, and the Netherlands and Sweden will also find ways to intervene. Spain is the old hegemon of the Caribbean, and the whole of North America seems to be extremely large, but in fact, our living space is not as big as we imagined. ”

After Su Zining finished speaking, he seemed to feel that he was thinking a little too far, so he squeezed out a smile: "These are just the history of the past, maybe our butterfly wings are already changing these." But I fear that this butterfly is also accelerating changes that are not good for us. ”

"Yan Xiaosong and you, it's for these reasons that you work so hard to run around, right? But how many of you really understand this? Many people probably think you're in the limelight. Yuan Xinyi thought about it, sighed slightly, and then looked at the other party's arm with nothingness.

"Hehe, there must be someone who worries about the country and the people." Su Zining smiled, turned around, and continued to lie on the side of the boat in a daze

Seeing that the other party didn't seem to have any reaction, it took a long time for Yuan Xinyi to come back to her senses and walk towards the cabin with a hint of disappointment. Su Zining, on the other hand, continued to stand on the side of the boat in a daze.

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