After telling the story, Takado Fujioka stood up and turned on the light. "Children, don't worry too much, although this bacterium is dangerous, but we are on the airship now, this bacterium is very contagious, and it should not be able to infect our heads."

"Qianyu, what did he say just now?" Mitsuhiko asked impatiently. "What Gram stain, what Gram-positive bacteria, cefazolin, vancomycin, whatever......"

"Well, if you have to ask all of this...... Qianyu raised her eyebrows, and then looked at Gray Yuan. Are you coming to this? ”

"In a nutshell, Gram stain is a means of distinguishing the types of aerobic bacteria by which it is possible to divide aerobic bacteria into two types: Gram-negative and Gram-positive," explains Gray succinctly. "Cefazolin is a common antibiotic for gram-positive bacteria, while vancomycin is a heavyweight antibiotic for gram-positive bacteria used at the last minute."

"Is vancomycin powerful?" Mitsuhiko asked.

"It's amazing," Gray Yuan nodded. "So far, Mr. Fujioka's example is probably one of the very rare vancomycin-resistant bacteria in the world – if it hadn't worked because vancomycin hadn't had time to penetrate deep into the body."

"What's the deal with drug resistance?" This time it was Ayumi who asked. "Why do bacteria become resistant to antibiotics that kill them? Aren't antibiotics their nemesis? ”

"After all, they're just drugs," Gray Yuan shook his head with a smile. "Antibiotics don't have eyes, they can't see what bacteria are and what they aren't, and they can only rely on some special ingredients they carry to identify and come into contact with bacteria. But if the bacteria somehow make it impossible for the antibiotic to recognize them or contact them, then the antibiotic is not powerful at all – for example, vancomycin works by binding to the D-ALA-D-ALA (D-ALANINE-D-ALANINE), the precursor of the bacterial cell wall, to catch the bacteria before they can work. Once there are certain changes in the precursor that cause vancomycin to bind to the precursor, vancomycin is useless. ”

[Author: In reality, VRB-vancomycin-resistant bacteria (vancomycin-resistant bacteria) is because the structure of the precursor pentapeptide of the cell wall has changed, making it almost impossible for vancomycin, which is blocked by binding to the end of the pentapeptide, to bind to the D-alanine-D-alanine terminus, thus producing resistance to vancomycin. The current treatment for this drug-resistant bacteria is to combine dipyridinyl and vancomycin to form a dipyridylvancomycin conjugate, and the dipyridine group and zinc ions in the bacteria can form a complex, so that vancomycin will be carried by the dipyridine group and hung on the bacteria, and can still continue to achieve bactericidal function. 】

(If you want to put it simply, vancomycin needs to be hung on the bacteria to take effect, and the drug-resistant bacteria can't hang up because of the mutation, and then the improved version of vancomycin holds a universal glue glove that can be strongly bonded to a certain part of the bacteria, and then vancomycin can be successfully hung up and then hang the drug-resistant bacteria)

"What does that mean......" Yuan Tai was confused.

This explanation might be understandable to Chiba, Conan, or Takado Fujioka, but it was too difficult for these children.

"Let me give you an example," Chiba sighed. "For example, I'm vancomycin, and then Ash is—"

Qianyu's words were cut off in an instant after Gray Plains glanced at him.

"Well, if the police are vancomycin, the average bad guy is an ordinary bacteria, and then the police just have to find a way to find these bad guys, and then catch them, handcuff them, and these bad guys will be finished. Do you understand that? ”

Motota, Ayumi and Mitsuhiko nodded.

"But now there's vancomycin-resistant bacteria, like Kidd the Thief." Thousand feathers spread their hands. "Kidd is a thief with a lot of action, even if the police accidentally run into Kidd, Kidd can get rid of them through his own mobility, so the police can't catch Kidd at all, let alone handcuff Kidd."

"You mean that those resistant bacteria won't be caught by vancomycin?" Mitsuhiko said tentatively.

"That's right," Chiba nodded. "Do you understand this step?"

"Hmm!" Motota and Ayumi nodded.

"Now, then, we've equipped the police with a big fishing net," Chiba explained as she continued to open her mind. "This fishing net is very big and strong, as long as the police encounter the strange thief Kidd and throw the net out to catch the strange thief Kidd, he can no longer escape, and can only be handcuffed by the police honestly."

"I seem to understand?" After another fifteen seconds or so, Mitsuhiko said uncertainly.

"That's pretty much it...... "Chiba sighed." I'm probably going to go crazy if I go on...... If you still don't understand, come to me after tomorrow's takeoff, and I should have the heart to continue to break it down and explain it to you...... I hope you understand what I'm saying, and I don't need to say it again......"

"Children," at this moment, Takado Fujioka, who had been watching Ash Hara and Chiba, spoke. "You should learn from the two of them - maybe also from the glasses boy next to him who is not the slightest bit confused, the three of them have a lot of knowledge, and geniuses like them will be very popular in the future, whether they go to school or grow up, you must grow up to be knowledgeable like them!"

…………

On the way out of this room, Qian Yu took the initiative to find Gray Plains.

"The emergence of this antimicrobial resistance is too sudden, isn't it?" Qian Yu asked with a frown. "How did a strain that was completely resistant to vancomycin emerge all of a sudden?"

As a matter of biological knowledge, the emergence of drug-resistant strains comes from genetic mutations that are going on all the time, and the increase in drug-resistant strains comes from the screening of drugs - if there are 100 bacteria, one of them suddenly becomes a drug-resistant strain, then only 1% of the bacteria are drug-resistant strains. But if antibiotics are now dropped in the middle of these bacteria, then all but the only resistant strain will die, and only one resistant strain will remain, so that all bacteria will be resistant strains.

In other words, if they follow the laws of nature, they should find that vancomycin can kill most bacteria perfectly, but it is not effective against gram-positive bacteria in a very small number of patients.

Now, however, the vast majority of bacteria have not been fatally hit, suggesting that the percentage of these bacteria resistant to vancomycin may be very high.

In nature, this is almost impossible unless ......

"You mean that these strains were artificially released after they were developed to be strong enough to resist the drug?" Gray Plains frowned.