Chapter 818 – Cis A2B3

In front of them, a teenager who looked like Shinichi Kudo sat quietly by the river, and was draped in warm blankets by several villagers.

"Are you the new brother?" A hint of mockery flashed, and Chiba asked in the direction of [Kudo Shinichi].

"......" [Kudo Shinichi] turned his head with a rather languishing look and looked at them, only to find that there was some schadenfreude on the face of the person who had just called his name in a rather sincere-sounding voice. New ...... Is this my name? ”

His voice was hoarse, probably from the cold caused by the immersion in the water.

"Ah...... I'm sorry, he's our companion, I don't know why he separated from us before," Dr. Asasa hurriedly said to the person next to him, and the others immediately believed Dr. Asasa's words and left in twos and threes. And it wasn't until most of the passers-by had already left that Dr. Asa looked in the direction of [Kudo Shinichi] like Chiba and Conan,

To be precise, it should be behind [Kudo Shinichi], because there is still a person there who is still squatting in the blind spot of the field of vision behind [Kudo Shinichi].

"Yes, of course that's your name, otherwise would you have anything else to call it?" He asked rhetorically in a voice that made [Kudo Shinichi] jump his eyelids for a moment.

"......" But [Kudo Shinichi] remained calm, just turned around and looked in the direction of the person who said the sentence just now. But immediately after that, he showed an irrepressible look of consternation. “!?!?!?”

Kudo Shinichi, who was supposed to be locked in a cabin with a latch, was crouching in front of him at this time, looking at him expressionlessly.

On the other side, the faces of Dr. Asasa, Conan, and Chiba were full of expressions of watching the show.

"How's that," Kudo Shinichi said to the imposter in front of him. "Didn't expect that, did you? Mr. Impostor, I don't seem to be locked up by you. ”

"You ......," [Kudo Shinichi] said in a hoarse voice, alarmed. How do you know...... How did you get out? ”

"I've been following him, and after seeing you lock him up and leave, I'll get him out - don't really treat us like puppets who can't resist anything, we also have a plan in advance!" Chiba unceremoniously reprimanded the man who looked to be in his teens much older than her - although this face should undoubtedly be the result of transfiguration or even plastic surgery, his body skin should also look quite young, so he should also be a young man under 30 years old.

"So, who is your real identity, and why do you want to disguise yourself like this?" Conan stood in front of [Kudo Shinichi] and tried to touch the edge of his face with his fingers, only to find that the other party did not seem to be disguised, but really had irreversible plastic surgery. "Wait a minute, what are you...... Is there a permanent facelift? Plastic surgery to look like Shinichi Kudo? ”

"If you want to use my face, imprison me...... That means you want to borrow my face for something that can ruin my prestige, right? Kudo Shinichi looked at the imposter and asked.

"You...... Why did you make such a judgment to the village chief's family in the first place? After a long silence, Makoto Yada asked.

"You mean the cancer thing? Just for this matter, you don't even want to find a way to confirm with me in advance, or even argue with it, you have to make yourself plastic surgery like me...... What does my friend Shinichi Kudo look like? Conan almost slipped his mouth before he reacted.

"......" [Kudo Shinichi] glanced at Conan. Of course, I confirmed - or rather, what Kudo Shinichi asked the police to tell me before, I know it, and I also know that the so-called village chief is AB blood type. Kudo Shinichi, that's what you judged based on this incident that the big tree wasn't the village chief's biological son, right? Because the village chief's wife has type O blood, and the big tree is also type O blood, the inheritance from the village chief must be the same O as his wife. According to common sense, the village chief's blood type is AB, so the only thing he can pass on to his offspring through genes is A or B, and finally he and his wife's O are combined into AO of blood type A and BO of blood type B, right? ”

"If you know such a thing, why should you question the judgment itself? Or are you going to start with something else? Dr. Asasa asked with a curious expression.

"Are you...... Makoto Yada? The adopted son of the village chief's family? Conan, on the other hand, gave a different question - he didn't tell too many people that the village chief forced his wife to commit suicide because of the infidelity to the marriage inferred by blood type, so it was not difficult to deduce the identity of the other party. The Makoto Yada who was adopted by the village chief, but did not change to the village chief's family name? ”

"Well, I'm Makoto Yada...... As for why I question the assertion, it's because the village chief's father is also type AB, and his mother is type O, do you know what I mean? Saying this, [Kudo Shinichi], or Yada Seito turned his head and looked at Kudo Shinichi.

When Conan showed a surprised expression, Chiba didn't look particularly surprised.

Common blood grouping is often determined by serology - in a more popular way, it can only detect what kind of blood group-related genes the holder has, but cannot determine where the genes are located.

Of course, for the average person, mastering the three genes iA(A), iB(B), and i(O) together to form an allele can already be a qualified intelligent citizen in this regard. But in fact, it doesn't seem that these three genes necessarily have to correspond exactly to each other at the DNA level, because there is a real possibility that some of these genes can coexist with each other. (whether due to accidental gene exchange or gene mutation)

iA+iB, also known as trans-AB blood type, is the way genes are distributed in common AB blood types, but they are not the only ones.

iAB+iO, or in the terminology, Cis-AB (cis-AB), two genes of AB are located on the same chromosome at the same time, so that AB binds to each other, and the frequency in the population is about 0.018%.

It is important to note that cisAB blood types are not completely consistent even between blood types, and there are at least a number of subtypes such as CisA2B3 (A2B3+O), CisA1B3 (A2B3+A1), CisA2B (A2B3+B), etc., depending on the serologic characteristics.

And if the head of Hihara is this particular cisAB blood type, then his child's O blood type is something that can be fully explained.

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The frequency mentioned in this article comes from Yamaguchi's research report on Japan. At the same time, the two cases of CisAB blood type he reported were both of the A2B3 subtype