Chapter 669: Cross-Blood Heart Transplantation

Yang Ping sent his wife to the gate of Sanbo Hospital, and then drove to Nandu Fuyi.

He was already very familiar with the attached one, and when he came to the attached one, he parked the car and called Professor Yao, who immediately went downstairs to greet Yang Ping.

The organ transplantation center attached to Nandu enjoys a high reputation in China because of Professor Yao's ischemic transplantation technology.

Professor Yao took Yang Ping to the doctor's office, and the doctors here are not very familiar with Yang Ping, unlike orthopedics, almost everyone knows this Professor Yang.

"This is Professor Yang from Sanbo Hospital!" Professor Yao introduced Yang Ping to several chief physicians in the department.

Several chief physicians just nodded symbolically, such a young professor has never seen it, and it is not a character in comparison.

Professor Yao asked the doctor in charge of the bed to bring the medical records, and Yang Ping read the medical records in detail, not letting go of a word.

Xu Jiujiang, male, 45 years old, diagnosis: dilated cardiomyopathy.

Since 3 years ago, as long as Mr. Xu moved a little, he would have a feeling of heart season, shortness of breath, and hypoxia, and was diagnosed as dilated cardiomyopathy by a local university hospital, and then the hospital has been treated with standardized anti-heart failure for 3 years, and his condition has not improved, 4 months ago, Mr. Xu's condition began to deteriorate, frequent episodes of chest tightness, heart seasons, shortness of breath, dizziness, unable to lie down, and unable to eat.

This made Mr. Xu feel deeply desperate, knowing that his time was short, but the child was still in high school, and Mr. Xu was unwilling.

In order to seek a glimmer of life, Mr. Xu went to the First Affiliated University of Nandu to find Professor Yao, who conducted a series of examinations on him.

Among them, the heart ultrasound shows that the diameter of the left ventricle has been expanded to 76 mm, while the left ventricle of normal people is about 45 mm, and the volume of the heart is more than 2 times larger than that of normal people, and the heart function is very poor, and the left ventricular ejection fraction has dropped to 28%, while the normal person is at least 50%, this kind of heart has reached and is dangerous.

After being hospitalized in Nandu No. 1 Affiliated Hospital, Professor Yao actively treated him with anti-heart failure, but Mr. Xu needed dopamine and norepinephrine to maintain his blood pressure because of fluctuations in systemic circulation and disorders in his internal environment.

In order to alleviate the condition and get the opportunity to wait for the heart, Professor Yao installed an intra-aortic balloon counterpulsation device for Mr. Xu to assist the left ventricle.

Yang Ping has already understood Mr. Xu's basic condition, and now he revisits it and is more familiar with it.

"There is only one chance for a heart transplant, so please come over and discuss together, I once did a heart transplant with different blood types, that is, a donor of type O blood transplanted to a patient with blood type A, because blood type O can be "compatible" with blood type A, plus the use of new drugs, the risk of rejection is more controllable, so we dared to try at that time, now this patient is blood type B, the possible donor is blood type A, completely incompatible blood type, in heart transplantation, we dare not try. ”

"If you are a young child and the immune mechanism in the body is not complete, you can try to perform a cross-blood type transplant, which may "fool" the immune system, but in adults, the immune system is intact, and there is no way to try it. ”

Professor Yao was very polite and expressed his difficulties and worries.

At present, if the cross-blood type transplantation of kidney transplantation is applied to heart transplantation, it still seems a bit rough and inappropriate.

Yang Ping admires Professor Yao a lot, his ischemia-free transplantation technology is world-class, but it will take a certain amount of time to perfect, he pushed it with his own hands and accelerated it, but he didn't expect Professor Yao not only not to be angry, but to respect himself so much and put himself in the position of learning.

Professor Yao really has the demeanor of everyone, and Yang Ping decided to transfer some of his experience to Professor Yao without reservation.

ABO blood type is the basic principle of organ transplant pairing, and if the blood types are incompatible, the transplant will have a strong immune rejection response after surgery.

If a cross-blood type transplant is to be performed, it is necessary to either thoroughly wash the antibodies or strongly suppress the immune system, so as to ensure that there is no strong immune rejection, so that the transplanted organ can be safe and integrated into the human family.

Several chief physicians around him didn't understand why Professor Yao had so much respect for this young man.

Yang Ping thought for a moment and said:

"Professor Yao, in fact, this case still needs to use the method of blood washing, but a more advanced method of blood washing is needed, there is currently a new method, the research team of the University of Toronto, Canada, uses FpGalylase and FpGalainidase two enzymes and supporting technologies to clean blood group antibodies, which can completely clean AB blood group antibodies and transform organs into universal donors, it is recommended to use this technology."

Ordinary blood washing techniques can no longer complete such a difficult blood washing, and new technologies can only be used.

"I've also read this paper, but it's still an experimental technique, and I don't know if the technology is mature, and it's unlikely to get this set of enzymes and related technologies." Professor Yao was in a dilemma.

It's not realistic to use this cutting-edge technology, and if nothing else, getting this set of enzymes is a problem.

"Now this patient is to be saved, there are only two ways, one way is to get a heart donor with the right blood type, and the other way is to get the University of Toronto's method, which one do you think is more likely, the former is completely by luck, to have the luck of winning the five million lottery, and the latter can work hard to achieve, if Professor Yao is willing to give it a go, I can help contact the University of Toronto team, and invite you to Professor Li Zehui at Cleveland Clinic, as well as his senior brother Dodge, are giants in North American cardiac surgery, Totally help to contact the University of Toronto. Yang Ping advised Professor Yao to give it a go.

Yang Ping calculated that if this patient did not have a heart transplant, there was no chance.

Of course, there is another way, to carry out an artificial heart transplant, get a buffer time, and then wait for the heart transplant, but the cost of an artificial heart suitable for this patient is not affordable by ordinary people, and even if you wait, there is still no chance to get a heart of the same blood type.

Professor Yao pondered for a moment, then decided to listen to Yang Ping's words and give it a go.

"Then you have to trouble Professor Yang to help me contact the team at the University of Toronto?"

Since lending a machine to Yang Ping for surgery and getting to know Yang Ping, Professor Yao has found himself as if he was leaning on a big tree.

"Okay, I'll send an email later, you take the time to fly over and learn their techniques, in fact, I am familiar with their techniques, but you have to get their two kinds of hemolamines, if you want to prepare these kinds of hemostasins, it will take a long time."

Yang Ping's reassurance was to reassure Professor Yao that he was not recommending new technologies to him based on a single paper.

This new technology is indeed very familiar to Yang Ping.

Because in the system space, when Yang Ping reads papers, when he sees new achievements that he is interested in, he will find a way to do experiments in the system laboratory to have fun.

The chief doctors who stood by and listened to Yang Ping and Professor Yao discuss their condition were like listening to a book from heaven.

What is the team at the University of Toronto, contact when they say contact, and also, Cleveland's Li Zehui and Dodge seem to be his brothers, as if he sends an email, and others will definitely help him.

And when he said this, he seemed to be very domineering.

Professor Yao was very excited to learn from the University of Toronto's recent AB antibody washing technology and get access to two of the most advanced enzymes.

With this alone, I can take several steps in the field of organ transplantation.