After Yao Yue started working, she was still a little nervous. ｛｝

But soon, she realized that she didn't need to be worried.

Because Yang Rui works extremely seriously, he has no time to care about whether her dress and white coat really accompany each other.

The amount of work required to produce CoQ10 from plant extraction is simply too large.

In particular, Yang Rui is ambitious and wants to establish a research and development chain, and this task is even heavier.

In order to produce cheaper CoQ10, the most important step is to extract the intermediate product solanesol from tobacco leaves, and then use solanesol as the intermediate product to chemically synthesize CoQ10.

In fact, there is already a technology for extracting solanesol from tobacco leaves.

Even using solanesol as a raw material to chemically synthesize coenzyme Q10, there have been related papers and practical results in 59 years.

However, a dissertation is a dissertation after all, and research is research after all. Just like the pure chemical synthesis of coenzyme Q10, there have been related papers and studies since the 60s, and more than one team has obtained coenzyme Q10 by chemical synthesis. However, it was not until half a century later that the chemical synthesis of CoQ10 could not be industrialized.

It also took about 30 years for the semi-plant extraction and semi-chemical synthesis method to mature, and the key factor is to use 90% purity solanesol as the raw material.

Now that he realizes this, Yang Rui may be alone in the world.

It can be said that just one sentence can be exchanged for an industry worth billions of dollars in the future.

It's a pity that Yang Rui can't just say it.

If he uses a real yàn, a paper to say, he may be highly praised and affirmed by the biological community, but there is no need to think about money.

Japan, West Germany, the United States, France, the United Kingdom...... There are too many super pharmaceutical companies, and they can use strong research teams and lawyer teams built with pure gold to throw Yang Rui out of the income zone.

It is somewhat arbitrary to say that Big Pharma is the most despicable company in the world, but whoever wants to say that they are not despicable must get a bad win.

Even the employees of pharmaceutical companies dare to say that our company is charitable, but they dare not say that their company is charitable.

Therefore, Yang Rui must build a series of key technologies around the core technology, and then use a series of technologies to focus on a series of key technologies.

For example, the synthesis of 90% pure solanesol requires a series of key technical supports.

The advantage of this kind of barrier is that Yang Rui does not need to apply for a patent for the core technology, or simply make a patented submarine, and only produce finished products for sale in a strictly confidential way.

This is also the magic weapon for small and medium-sized biotech companies to survive.

In the early '80s, many biotech companies didn't understand this, thinking that patents could protect themselves, and as a result, they were killed by big pharma one by one.

At that time, the average life expectancy of biotech companies in the United States was only 36 months, and most medium-sized biotech companies with a capital of less than $50 million would not survive even 18 months if a lawyer's fee was added.

At the level of big pharma, not to mention 18 months of delay, they have more than 8 years of lawsuits.

This is also one of the reasons why Yang Rui does not dare to make medicines for the time being.

Western medicines have a fixed name, usually a chemical compound. And most of them are derivatives of compounds known to the pharmaceutical community, except for the branched side chains, which is not surprising.

For example, this drug is very simple to be imitated, and if it is profitable, it is almost natural to be imitated.

The production technology is different. As long as the secrecy is done well, coupled with a certain amount of technological upgrading, it is no problem to maintain monopoly interests for several years.

Biotech companies monopolize and make money for a few years, no matter how small the field, means a huge amount of money.

Japanese pharmaceutical companies, using semi-plant and semi-chemical synthesis, that is, five or six years, have accumulated enough funds to complete the thorough development of microbial fermentation methods, and at the same time dividends are soft.

Yang Rui has now developed the technology of plant extraction and semi-chemical synthesis, and the money he can make can be more than a few years.

Thinking of this, Yang Rui is also full of energy.

In just one weekend, a few verifications were completed.

He didn't mean to stop, he continued to find a few journals, continued to do verifying the facts, and at the same time, Yang Rui also began to write the first review.

In the academic community, the review can be regarded as a high-level popular science.

A review is a paper in which the author reorganizes the numbers, data and opinions of a large number of papers for a certain topic, and then analyzes and refines the papers.

To put it simply, Yang Rui only needs to summarize the articles he has read recently around a proposition, which can be regarded as a review.

For example, "The Current Status of Solanesol Research" is a common review article.

However, it is more difficult to publish this kind of article, and it is even more difficult to publish it in a better journal.

In Europe and the United States, especially the United States and the United Kingdom, it is often the experts in the field who write reviews, and there is a feeling of giving lectures to ordinary researchers in simple terms.

Of course, their motives for writing reviews are usually not so pure. Most of the time, Da Niu writes reviews in order to mix up paper indicators. Because many foreign schools also have hard requirements for how many papers to write every year or every few years, some big bulls either out of laziness or out of excellence, unable to complete the required number, write a review to pass the test.

Because it is a high-level popular science, you don't need to study deeply, and after checking some information, you can usually write a review in a few days.

Domestic reviews are often written by gentlemen who are far away from the big bulls. Some master's students who can't get a thesis or want to mix up a sci, some young lecturers who can't complete their tasks, or busy associate professors are all big contributors to the review, and the water level is naturally uneven, so that some departments simply list the review separately.

However, in the 80s, the Chinese academic community was not so particular, limited by the level, and the review was still a very popular category.

Yang Rui didn't want to waste himself checking so much information, and the more papers with technical barriers, the better, so he started writing unceremoniously.

Lu Zhi, who was helping in the room, saw that he wrote easily, and wrote a large page in one afternoon, and couldn't help asking: "You said that writing a paper is like this?"

"This is the first article, starting with the simple. Yang Rui is not slow to write papers, because a lot of information is stored in his mind, and he has a clear understanding of the future development direction, so it is naturally easier to write a review.

Seeing that what he wrote was in English, Lu Zhi naturally knew that he was going to publish it abroad, so he couldn't help asking, "Can it really be published?"

Yang Rui said angrily: "I can't publish it, what am I writing to do." ”

"It's normal that you can't publish an article, many brothers and sisters are desperately trying to change it, and some have to change it for several years. "What Lu Zhi said is still a struggle type, if he is not struggling enough, he can't think of publishing articles abroad.

Yang Rui smiled disapprerovingly: "I'm different from them." ”

Now, even Yao Yue asked, "What's the difference?"

"Talent. Yang Rui pointed to his head and said half-truthfully: "I have a lot of things in my head." ”

"You're trying to say I'm empty-headed. "Lu Zhi is not skilled enough, she doesn't have many opportunities to contact the instrument, not to mention the unfamiliar instrument here for Yang Rui, in the past two days, her cousin is not as good as middle school student He Cheng, and she has accumulated some affection.

A stupid girl like Lu Zhi immediately poured out an idea and couldn't save it.

Yang Rui laughed twice and acquiesced silently.

Lu Zhi was angry, grabbed Yao Yue and said: "Let's go, don't do it for him, not only tired, but also scolded, he is simply a capitalist." Whoever you, who's the puppy. ”

Yao Yue was in a dilemma, and Yang Rui said faintly: "The canteen makes braised pork at noon, thank you." ”

Lu Zhi stopped unconsciously, and after a while, he called softly: "Wang!"

Yao Yue couldn't cry or laugh, so much so that he said ashamedly: "Lu Zhi, you can't ...... at every turn."

"Just what?"

"It's called ......" Yao Yue stomped her foot before she finished speaking.

Lu Zhi said indifferently: "What is this, when you know the youth, if you make a pot of braised pork in the kitchen, everyone can line up for a day." If the order is finished, and there is no braised pork, everyone can rush up and bite the captain to death in the kitchen. ”

The last sentence is obviously a threat to Yang Rui.

"Have you ever been an educated youth?" Yang Rui hurriedly diverted the topic.

"There are a lot of educated youths in school, and I went home and repeated my studies for a year before I was admitted, but fortunately I was admitted, otherwise I would have to go to the coal mine. A former classmate of mine went down to the coal mine to do beneficiation for two years, and he couldn't sleep at night with tinnitus, saying that his head was full of machine qì sounds. Lu Zhi complained mixed with rejoicing.

He Cheng, who has always been bored and practical, heard this, and suddenly said: "My second cousin sold the family's pigs in order to enter the coal mine last year, bought cigarettes, alcohol and gifts, and arranged temporary workers. Their family eats vegetarian dumplings during the Spring Festival. ”

Going to the coal mine is not as good as studying, but being a farmer is not as good as going to the coal mine, this answer immediately silenced the two college girls.

Yang Rui didn't like this atmosphere, coughed, and said, "Yao Yue, you also write a review and show it to me next week." ”

"I, I still can't understand some words......" Yao Yue was slightly nervous. Nowadays, there is no search engine that can help translate English, and the words you don't know have to be found one by one.

Yang Rui shook his head: "It's not for you to write in English, first write a Chinese one, anyway, it's not wasted, it's considered to accumulate some experience." After the paper is written, I will help you revise it, and then teach you to write a cover letter, and the signature is also your own. ”

Just like a big bull in later generations, Yang Rui doesn't bother to leave his name in ordinary journals in China at all, let alone this kind of review of small articles like practicing writing.

Yao Yue relaxed for a moment, became nervous again, and whispered, "Can I write it?"

"How do you know if you don't try. Alright, go pack your bags and go back after lunch. Yao Yue, do you have a problem...... Mail it to me, write a letter, well, I have asked you to do it, and I will also write to you to explain the requirements and steps, and you will mail back the details when you have the result. Memorize English words and start reading English literature next month. Except that the email became a mail, Yang Rui's request was similar to that of his supervisor when he was in his second year of graduate school.

There are few graduate students in these years, and excellent undergraduates originally had to take on the task of assisting her, Yang Rui now has an understanding of Yao Yue's ability to do so, as long as she doesn't assign tasks that exceed her ability, there won't be too many mistakes.

Lu Zhi silently recited the braised pork and went to the dressing room briskly, Yao Yue left a little hesitantly, not only with nostalgia for the real room and people, but also with expectations for writing his paper.

"If the classmates in the class knew that I had the opportunity to write a paper for publication, they would be envious. Yao Yue's vanity also fermented slightly. She is only a sophomore girl this year, and if she has the opportunity to publish a paper, she will be the person of the year at Hedong University.

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