"This is the number one priority $ project, and this is the most important project in the years since my lab was established. Yang Rui persuaded the people in the laboratory, and also persuaded the lawyers who rushed from Hong Kong.

Of course, a lawyer is paid and has to work no matter what, but whether or not he understands the importance of the project also determines how he works.

Big-name lawyers can make money anywhere, and they will be like taxi drivers on rainy days, simple patents have no benefits, you can do it more easily, this kind of patent, may not meet a lawsuit challenge in a lifetime and expire, and Yang Rui's expectation of a watertight patent is time-consuming and labor-intensive, I want people to help you do it seriously, and you have to prove that your patent is worth doing.

Lawyer Yue Ting took two assistants with great professionalism and listened carefully. He has been a patent attorney for more than 30 years, and he graduated from the Department of Physics of the University of Hong Kong.

That is, about half an hour, Yue Ting proposed to see an X-ray.

DNA is invisible to the naked eye, not visible with an ordinary microscope, but in fact, it's idle to see it, and you don't know it.

28 base pairs of DNA, even if you ask it "who are you", you will not receive an answer.

To prove the success of PCR, the hybridization signal on the X-ray plate is used.

Yang Rui looked at another company lawyer next to him first.

The company's lawyer is also from Hong Kong, but he belongs to the company lawyer who has been signed by Sinovel for a long time, and belongs to Yang Rui's own people. After the latter nodded, Yang Rui went to get the X-ray.

In fact, there is nothing to hide, this thing that belongs to the professional category cannot be copied away.

The reason why Yang Rui redid the experiment was to have these seemingly useless proofs.

Otherwise, he just copied the paper.

However, if you just copy the paper, you will not be able to pass the academic review one after another.

Many of the papers that changed the world were short – Tu Youyou's Nobel Prize-winning paper was titled "A New Type of Sesquiterpene Lactone - Artemisinin", signed by the Artemisinin Structure Research Collaboration Group, and the full text was only one page. The DNA double helix written in each student's textbook also won Watson and Crick the Nobel Prize, and the full text is only half a page.

Long papers are rare, and such short papers are also rare.

At the very least, it's hard to copy, and applying for a patent can't be like a paper.

Applying for a patent is a chatter, how many and how to come.

Some large companies, in order to apply for a patent, will list hundreds of parallel patents, all to protect the core patents in the middle.

Therefore, many large companies have tens of thousands of patents a year, not that they really have tens of thousands of patents, it is very good to have a thousand, and the rest are some popular patents.

However, a patent that is praised also needs to be carefully written, which consumes the time of the lawyer, the time of the patent office, and in the final analysis, it costs money.

And it's expensive, it's expensive.

This is especially true for mainlanders in '84.

Yue Ting calculated a number in his heart, and shook his head in his heart.

Of course, he wouldn't say to Yang Rui, "You don't need to patent this research like this", if he was a white man, he would make money first without saying a word.

Facing Yang Rui in the mainland, Yue Ting had the intention to save some money for Yang Rui, but he also felt that it was too troublesome, and thought about it: "I understand what you just said, but I think the cost is a bit large, especially what you requested, to apply for multiple patents in one go, and to apply for patent protection, the cost of this will not be less, calculated down, at least millions of dollars, and, because of the salary of other lawyers, the amount of this part is uncertain, only a lot more." ”

On the one hand, he was scaring Yang Rui, and on the other hand, he was telling the truth, if he followed Yang Rui's requirements, he would have to pay millions of dollars, and it would be nothing less.

If you encounter a patented submarine, you have to go through a lawsuit.

And if you want to make your own patented submarine, you have to spend a lot of money.

Patent barriers have always been something that large companies like, and small companies can only do this steadily, which is an act of self-defense.

Yang Rui has carried out a series of patent applications for the patent of coenzyme Q10, but the requirements at that time were more than an order of magnitude different from now. The same goes for the strength and price of the lawyer who is hired.

However, coenzyme Q10 is only a billion-dollar market, and the profits distributed to Jielikang are billion-dollar dollars, and the million-dollar profits are distributed to patent owners.

PCR is a terrible monster. It was perhaps the first blockbuster in the biotechnology sector, eventually creating a market worth $100 billion, with the technology patents represented by the PCR historically worth $3 billion.

It does not yet include the controversial high-temperature polymerase.

Now, Yang Rui has made up for the shortcomings of high-temperature polymerase, and profits may rise sharply.

In his heart, Yang Rui will apply for a patent at any cost.

However, it has always been a false proposition at any cost, money is the last word, and money will always be the bottleneck.

Yang Rui didn't have a million dollars in his hands.

Recently, Sinovel Labs has been spending money like water, and he still doesn't dare to cut it off...... Although the PCR experiment can be patented, there is still a distance from the complete completion of the academics, and it still needs to continue to invest, and there is no return in the short term, he will have to apply for more patents in the future, including the patent of PCR, and maybe Huang Mao and others have made results, where money is indispensable.

Enterprises will have problems with the capital chain, and laboratories will also have them.

And Yang Rui's income is only Jielikang's dividends.

Once every three months, now it can be a million dollars at most, and only seven or eight hundred thousand when it is less.

If this money is used for personal life, the rich do not know how to spend it, and they can buy a Ferrari in a few days.

However, I don't know how many things are more expensive than Ferraris in the lab......

Yang Rui was also silent.

"Mr. Yang Rui, you should also pay attention to the issue of patent disclosure. Of the world's major patent countries, only a few countries, such as the United States, do not have a patent disclosure system. But if you're going to apply for a patent in multiple countries, you need to make the patent public, anyone can search for it, and if you find it, your technology may face competition. Yue Ting knew that Yang Rui's research was not completely completed, so he wanted to persuade Rui from this perspective.

Yang Rui didn't think about it and said: "It's impossible for others to do it faster than me, even if it's made public, it's too late for them." ”

"But disputes can add to the cost. ”

"There's no way around that, you can't just stop applying for a patent. Mr. Yue, for the PCR project, I would rather go bankrupt to do it, please take the trouble to ......"

Yang Rui said this, Yue Ting, as a lawyer, could only nod and said, "Okay, I'll finish the preparation and application as soon as possible." It takes up to a month for you to have access to public records. ”

"In other words, I have a maximum of a month before the patent is published?"

"Maybe only twenty days, if our application goes well. We are professional patent attorneys, much faster than ordinary patent firms. Yue Ting was quite proud of this.

Yang Rui nodded slightly and said, "So far, I have carried out the project independently. Now that the original stage is over, the next step is to enter the verification and refinement stage, and I am ready to involve the staff of the laboratory, is that appropriate? ”

"Of course not. Yue Ting laughed.

Sinovel's corporate lawyer also explained: "You can rest assured that the employees have signed strict confidentiality agreements and have waived their claims. ”

"I want both of you to conduct a separate re-check. ”

The company lawyer was a little unhappy, but could only say, "I will give a copy to Mr. Yue." ”

"Independent review, if you have any questions, please report to me separately, it doesn't matter if there are loopholes in the previous contract, we can resign now." I don't want anyone else to step in and there will be another loophole. ”

"You really should be a lawyer. Yue Ting disagreed with Yang Rui's caution, but he understood Yang Rui's importance to this matter, and he also straightened his attitude.

For patent attorneys, they don't need to judge the value of patents, the employer's attitude is everything. If the employer feels that he has invented the Fragrance Law, then what the patent attorney has to do is to protect the Fragrance Law without scoring the degree of fragrance of the Fragrance Law.

"Don't be afraid to waste paper, the contract must be tight. Yang Rui told again.

This is a Nobel Prize-level achievement, and I don't know how many of my lab colleagues have filed a lawsuit for it. When Waxman discovered streptomycin, he was sued by his doctoral student Saz - he was the direct discoverer of the streptomycin strain - and finally the two settled out of court, and Rutgers University issued a statement acknowledging that Saz was the co-discoverer of streptomycin in the legal and scientific sense, and gave Saz $120,000 in foreign patent income and 3% of the patent income......

In this regard, the academic community naturally does not agree, Saz is nothing more than a head dog under Waxman, and Waxman's laboratory has 50 scientific research dogs, when Waxman takes the right screening, any one of the fifty scientific research dogs, it is possible to find streptomycin, it is nothing more than a matter of time.

The later Nobel Prize did not have anything to do with Saz, and the so-called co-discoverers in the scientific sense were not recognized by any scholar at all.

In the end, Saz had no place in the academic world, but he did take the patent share.

Yang Rui didn't want this to happen to him.

When he was in graduate school, he was surrounded by graduate students and doctoral students like Saz. When everyone is drunk, they will say, "I did all the work, but the result is the boss's, and the first author is the boss's...... It's not fair!"

Yang Rui is a proponent of this injustice. Workers deserve respect, but they are not competitive, nor are they entitled to be rewarded for the results of their intellectual activity.

The manual labor dogs in the world of scientific research are not even human, and where are they eligible to get awards and money!

Since Saz and Waxman, laboratories in various countries have also updated their laboratory rules and contracts, and there are countless templates, and Yue Ting and the company's lawyers have learned about Yang Rui's psychology and have been busy with their own work.

That night, Yue Ting and the company's lawyer met with Yang Rui separately to revise the contract.

The next morning, Huang Mao and others resigned the contract and began to participate in the PCR project.

It is true that they have not participated in the discovery of PCR, and it is natural to give up the relevant rights, and in addition, they will not realize the strong potential of PCR like Yang Rui.

At the request of Yang Rui, in addition to Huang Mao and Tu Xian continuing their original projects, Wang Xiaoyun, Wei Zhenxue, Li Wenqiang, Duan Bo, and Zhang Xuetong have all joined the PCR project team one after another.

Their job is to complete a PCR experiment with the highest "golden rules".

The gold rule requires a single copy of a gene to be amplified from 1 microgram of human DNA.

This will be a long and arduous process, for the first generation of PCR technology, for Li Wenqiang and others who have just come into contact with PCR, and even more so for Zhang Xuetong, who is responsible for the production of oligonucleotides and other raw materials.

Yang Rui began to write his dissertation independently.

Unlike potassium channel projects, PCR technology is simple, simple and perfect, and has a long history.

……

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