For Nova Company, rannizumab is about billions of dollars in annual sales, but how big is the Chinese market now? Compared to these two things, it is clear that the former is more important.

Moreover, they do not believe that with the current level of pharmaceutical products in China, they can develop any drugs that can have an impact on their products, just like Roche did back then.

After Roche bought the patent for the "two-stage fermentation method" of vitamin C, it was only used as a defensive strategy and did not use this method to produce, on the one hand, they wanted to continue to maintain a very high entry threshold, on the other hand, they did not believe that the Chinese method was an advanced method, and they did not believe in the Chinese's research and development capabilities and production capacity.

The consequence of this move is that with the development of reform and opening up, China's vitamin C production has continued to expand, in addition to meeting domestic demand, and even sold abroad, which has a huge impact on the vitamin C price alliance of Roche, Takeda Pharmaceutical, and BASF, and Roche has to start cutting prices.

It took them more than a year to beat the price of $18 per kilogram to $4 per kilogram, and the cost of Roche's use of the "Lai's chemical method" is extremely high, and four dollars has fallen below their cost price, and they plan to use their strong financial strength to beat Chinese producers to death, and then raise prices again.

However, even if it is four dollars per kilogram, domestic producers using the "two-stage fermentation method" still have enough profit margins, and domestic manufacturers have not fallen, and Roche and other companies will not be able to withstand it first.

Roche Pharmaceuticals sold its vitamin C production plant, and Japan's Takeda sold the vitamin C plant to BASF in Germany after the shutdown, and then BASF could not bear the strong production capacity of the Chinese pharmaceutical factory, and soon stopped production, and since then it has only been responsible for providing citral and other production raw materials; In addition, they have also received high fines from many countries for price manipulation, which can be described as stealing chickens and rice.

Later, more than 90% of the world's vitamin C was produced by four Chinese pharmaceutical companies - Northeast Pharmaceutical, North China Pharmaceutical, CSPC Pharmaceutical Group and Jiangshan Pharmaceutical, and China has the absolute production and pricing power of vitamin C.

Roche, Takeda Pharmaceutical and other companies withdrew from the vitamin C market at the beginning of this year, and now it has not attracted the attention of Nova Company, and the technical requirements for the development and production of vitamin C and the requirements for the development and production of anti-leukemia drugs are completely different, so Nova does not believe that China can manufacture this drug at all.

The person who reported earlier just mentioned it, and seeing that the executives didn't care, they didn't continue to insist, and quickly replied to Zhao Lizhong and asked them to deal with this matter by themselves, and Zhao Lizhong was in a predicament.

At the same time, several major media in Europe and the United States also received anonymous emails, in which the sender exposed the truth that Nova and other large pharmaceutical companies used many bribery methods to pass the FDA approval.

"What now? Do you want to publish the contents of this email? "Many media outlets have also begun to convene people to discuss this matter urgently, and they are not making any big news, pharmaceutical giants have always been their big advertising customers, and if they offend each other and people withdraw their ads, they will suffer huge economic losses.

However, there are both cooperation and differences between the media and pharmaceutical giants, which is just like the relationship between domestic real estate developers and the media in later generations. Otherwise, I'll expose you.

If there is a real big event, it must be exposed, otherwise the impartiality and ability of the media to obtain information will be doubted by readers and viewers.

"The sender of this email knows the media industry very well, see if he does not hide the traces of copying other media in the email, even if we don't send it, other media will send it! This is really big news, and if other media publish it and we don't, it will be a huge blow to the prestige of our newspaper. Someone reminded.

"Maybe we can contact the pharmaceutical companies first, let them know about it, see how they react, and if they can convince all the media, we'll leave it alone." It's also a good opportunity to blackmail pharmaceutical companies, depending on how much they're willing to pay and whether they can get all the media out.

"The sender also thought of this, and at the end of the email, he gave us a deadline, and if we didn't publish it after the deadline, he would post the message online." Someone reminded that "now that we are in the Internet era, traditional media like us can no longer fully control the right to speak." ”

"This is a cunning fellow, no matter what we do, sooner or later the news will be sent!" After the news spreads on the Internet, they still need to report it.

"Then inform Nova of them first, and tell them that we will ...... the day after tomorrow No, publish this email tomorrow and give them a day's buffer time, just thank them for their previous advertising money! The editor-in-chief was conclusive, "I hope their crisis public relations department can handle this." ”

"I don't think their PR department will have to sleep these days!" Some people joke that every time they encounter a time like this, the crisis public relations department will work overtime overnight.

"Let our reporters also take action, and everyone who can spare their hands will investigate and verify this matter, and strive to dig up more inside information!" The editor-in-chief decisively ordered that, according to the tips of this email, there is still a lot to dig into.

This is really terrible, it seems that not only those public relations people can't sleep these days, but also us reporters! The smile on the face of the person who had just joked froze, but it quickly cheered up, and it was also a great opportunity for them to dig up something truly valuable and become famous, and it was not impossible for them to take the road of promotion and raise, and become famous.

Nova executives were busy dismissing from Roche, academics, and public relations firms, when they suddenly learned such explosive news from the cooperative media, and immediately fell into a panic.

Now, they don't have the energy to worry about this little matter in China, and the news that Zhao Lizhong released at the beginning has become empty talk, and Shen Long won again in the second round of the competition.